反应详情

8-(2,6-dimethylbenzylamino)-2-chloromethyl-3-methylimidazo[1,2-a]pyridine (0.3 g, 1.0 mmol) and N,N-dimethylglycine (0.1 g, 1.0 mmol) were added to acetonitrile (10 ml) and the mixture was refluxed for 20 h. The solvent was evaporated under reduced pressure and the residue was purified by column chromatography on silica gel using, dichloromethane:methanol (10:2) as eluent. Recrystallization from acetonitrile gave 0.12 g (32%) of the title compound.

1. temperaturethe mixture was refluxed for 20 h
2. customThe solvent was evaporated under reduced pressure
3. customthe residue was purified by column chromatography on silica gel using, dichloromethane:methanol (10:2) as eluent
4. customRecrystallization from acetonitrile