Potassium sodium tartarate → HCID 9796757, compound

Participants

Reaction Steps

To an ice cooled solution of diethyl 8-(2,6-dimethylbenzylamino)imidazo[1,2-a]pyridine-2,3-dicarboxylate (2.5 g, 6.3 mmol) in toluene (100 ml) was added Red-Al (14 ml, 45 mmol)(65% in toluene) during 3 h. The temperature was allowed to rise to room temperature and a Rochell salt solution (35 g potassium sodium tartrate in 250 ml H2O) was added. The organic layer was separated dried and evaporated under reduced pressure. Purification of the residue by column chromatography on silica gel using dichloromethane: isopropylalcohol (4:1) gave 0.09 g (5%) of de desired product.

Provenance & Evidence