HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 4-(2,3-Dimethoxyphenyl)4-piperidinylmethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 4-(2,3-Dimethoxyphenyl)-4-piperidinylmethanone trifluoroacetate | HCID 21898109 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-(2,3-Dimethoxyphenyl)4-piperidinylmethanone | HCID 21898103 | — |
Reaction Steps
The resulting 4-(2,3-dimethoxyphenyl)-4-piperidinylmethanone trifluoroacetate was dissolved in water, treated with NaOH (10% aqueous) until basic, and extracted three times with dichloromethane. The combined organic layers were washed with brine, dried (MgSO4), filtered and evaporated to afford 4-(2,3-dimethoxyphenyl)-4-piperidinylmethanone as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06613779B2 |
| Source dataset | uspto-grants-2003_09 |
| ORD ID | ord-09e74ab676244511a0bb0bd2200896a2 |
| Source note | uspto-grants-2003_09 |