Hydrochloric Acid → HCID 22997652, compound

Participants

Reaction Steps

A solution of yield (3,4-dichlorothiophen-2-yl)-oxo-acetic acid ethyl ester (0.42 g, 1.66 mmol) in acetone (10 ml), water (2 ml), and conc. HCl (10 ml) was stirred under reflux for 1 hour. The reaction mixture was allowed to cool to ambient temperature then was concentrated in vacuo to provide a crude oil. The crude oil was purified by preparative HPLC to provide pure (3,4-dichlorothiophen-2-yl)-oxo-acetic acid as a yellow solid (85 mg, 38%). MS (M−H)−: 222.80; 1H NMR (300 MHz, DMSO-d6) δ8.38 (1H, s). 13C NMR (75 MHz, CDCl3) δ173.14, 159.44, 136.57, 133.43, 128.97, 125.20.

Provenance & Evidence