Hydrochloric Acid → HCID 22997622, compound

Participants

Reaction Steps

A solution of (3,4,5-trichlorothiophen-2-yl)-oxo-acetic acid ethyl ester (0.25 g, 0.86 mmol) in acetone (6 ml), water (2 ml), and conc. HCl (6 ml) was stirred under reflux for 1.5 hours. The reaction mixture was allowed to cool to ambient temperature then evaporation of acetone gave rise to solids which were collected, washed with water and dried. (3,4,5-trichlorothiophen-2-yl)-oxo-acetic acid was thus obtained as a light yellow solid (99 mg, 50%). MS (M−H)−: 258.74; 13C NMR (75 MHz, DMSO-d6) δ174.16, 162.74, 134.73, 130.43, 125.92, 125.26. IR (KBr) cm−1 3547.5, 2855.3, 2515.5, 1924.8, 1716.3, 1667.1, 1405.7, 1339.7, 1305.4

Provenance & Evidence