Hydrochloric Acid → HCID 12282383, compound

Participants

Reaction Steps

(2,5-Dichlorothiophen-3-yl)-oxo-acetic acid ethyl ester (4.51 g, 17.8 mmol) was stirred in a mixture of 100 ml water and 10 N NaOH (10 ml, 100 mmol) at room temperature for 20 hours. The reaction mixture was then acidified with 3N HCl, and extracted with ethyl acetate (3×50 ml). The combined ethyl acetate extracts were dried over Na2SO4 and concentrated under vacuum to provide (2,5-dichlorothiophen-3-yl)-oxo-acetic acid (3.90 g, 97%). MS (M−H)−: 223.02; 1H NMR (300 MHz, DMSO-d6) δ7.54 (s).

Provenance & Evidence