Methyl iodide → HCID 22997663, compound

Participants

Reaction Steps

A mixture of 2-nitro-4-chloro-6-allylphenol (21.7 g), methyl iodide (28.28 g), and potassium carbonate (16.6 g) in acetone (300 ml) was refluxed for 16 hours. After cooling to room temperature and filtration, the filtrate was concentrated in vacuo to give a residue. The residue was extracted with dichloromethane. The organic layer was washed with water, dried over MgSO4, and concentrated to give crude 2-nitro-4-chloro-6-allylanisole (21.6 g, 96%) which was used in the next step without purification. 1H NMR (300 MHz, CDCl3) δ7.69 (d, J=2.6 Hz, 1 H), 7.41 (d, J=2.6 Hz, 1 H), 5.97-5.89 (m, 1 H), 5.20-5.10 (m, 2 H), 3.88 (s, 3 H), 3.48 (d, J=6.65 Hz, 2 H).

Provenance & Evidence