4-(Methylthio)phenylboronic acid → HCID 88116418, compound

HRID 1166299Notes

Reaction equation

HRID 1166299 reaction equation
[SH:1][CH:2]([CH2:33][CH:34]([CH3:36])[CH3:35])[C:3]([NH:5][C:6]1([C:11]([NH:13][CH:14]([CH2:18][C:19]2[CH:24]=[CH:23][C:22]([C:25]3[CH:30]=[CH:29][C:28](SC)=[CH:27][CH:26]=3)=[CH:21][CH:20]=2)[C:15]([OH:17])=[O:16])=[O:12])[CH2:10][CH2:9][CH2:8][CH2:7]1)=[O:4].CS[C:39]1[CH:44]=[CH:43][C:42](B(O)O)=[CH:41][CH:40]=1>>[SH:1][CH:2]([CH2:33][CH:34]([CH3:35])[CH3:36])[C:3]([NH:5][C:6]1([C:11]([NH:13][CH:14]([CH2:18][C:19]2([C:41]3[C:40]4[C:39](=[CH:3][CH:2]=[CH:33][CH:34]=4)[CH:44]=[CH:43][CH:42]=3)[CH:24]=[CH:23][C:22]([C:25]3[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=3)=[CH:21][CH2:20]2)[C:15]([OH:17])=[O:16])=[O:12])[CH2:10][CH2:9][CH2:8][CH2:7]1)=[O:4]

Participants

3

Reactant 2

HCID 27339594-(Methylthio)phenylboronic acidHCID 22997551HCID 22997551, compound

Product 1

HCID 88116418HCID 88116418, compound

Procedure

2-{[1-(2-mercapto-4-methyl-pentanoylamino)-cyclopentanecarbonyl]-amino}-3-(4′-methylthio-biphenyl-4-yl)-propionic acid (from 4-methylthiophenyl-boronic acid; mp 187-189° C.

Sources & evidence

ORD record
ord-1a7b7d4771ca492795f7f9c5fc1d00f1
Source dataset
uspto-grants-2003_09
Patent number
US06613782B2

Reaction notes

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