Metrafenone → 6'-Butoxy-2,6-dichloro-4',5'-dimethoxy-2'-methylbenzophenone
Reaction equation
[Cl:1][C:2]1[CH:29]=[CH:28][CH:27]=[C:26]([Cl:30])[C:3]=1[C:4]([C:6]1[C:11]([O:12][CH2:13][C:14]2C=CC=[CH:16][C:15]=2F)=[C:10]([O:21][CH3:22])[C:9]([O:23][CH3:24])=[CH:8][C:7]=1[CH3:25])=[O:5].C(OC1C(C(=O)C2C(C)=CC=CC=2C)=C(C)C=C(OC)C=1OC)C1C=CC=CC=1.BrC1C=CC(OC)=C(C=1C)C(C1C(OC)=C(OC)C(OC)=CC=1C)=O>>[CH2:13]([O:12][C:11]1[C:6]([C:4](=[O:5])[C:3]2[C:2]([Cl:1])=[CH:29][CH:28]=[CH:27][C:26]=2[Cl:30])=[C:7]([CH3:25])[CH:8]=[C:9]([O:23][CH3:24])[C:10]=1[O:21][CH3:22])[CH2:14][CH2:15][CH3:16]Participants
4
Procedure
2,6-dichloro-4′,5′-dimethoxy-6′-(2′fluorobenzyloxy)-2′-methylbenzophenone (coded BB-2); 6′-benzyloxy-4′,5′-dimethoxy-2,6-dimethyl-2′-methylbenzophenone (coded BB-3); and 5-bromo-2′,6-dimethyl-2,4′,5′,6′-tetramethoxybenzophenone (coded BB-4), most preferred BB-4.
Sources & evidence
- ORD record
- ord-04c65e7ce7e94d0db2b1a42608ffb5c5
- Source dataset
- uspto-grants-2003_09
- Patent number
- US06613806B1
Reaction notes
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