Sodium Hydroxide → HCID 86595831, compound

Participants

Reaction Steps

N-(N′-BOC-3′-aminopropyl)-N-[(1-thyminyl)acetyl]glycine methyl ester (3.02 g, 0.00732 mol) was dissolved in methanol (25 mL) and stirred for 1.5 h with 2 M sodium hydroxide (25 mL). Methanol was removed by evaporation in vacuo, and the pH adjusted to 2 with 4 M hydrochloric acid at 0° C. The product was isolated as white crystals by filtration, washed with water (3×10 mL), and dried over sicapent, in vacuo. Yield: 2.19 g (75%). Anal. for C17H26N4O7, H2O, found (calc.) C, 49.95 (49.03); H, 6.47 (6.29); N, 13.43 (13.45). The compound showed satisfactory 1H and 13C-NMR spectra.

Provenance & Evidence