Propylene Oxide → HCID 178511765, compound

HRID 1166448Notes

Reaction equation

HRID 1166448 reaction equation
Br.[NH2:2][C@@H:3]([CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)[C@H:4]([CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[C:5]([OH:7])=[S:6].CC1CO1>C(O)C>[NH2:2][C@@H:3]([CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)[C@H:4]([CH2:8][C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1)[C:5]([OH:7])=[S:6]

Participants

4

Reactant 2

HCID 6378Propylene OxideHCID 178419708HCID 178419708, compound

Product 1

HCID 178511765HCID 178511765, compoundYield 65%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The hydrobromide was dissolved in 140 mL anhydrous ethanol, and 28 mL methyloxirane was added. The solution was heated to reflux for 1 hour under nitrogen. The solvent was evaporated to yield 0.45 g (1.45 mmol, 65%) of 8.

Workup

  1. temperatureThe solution was heated
  2. temperatureto reflux for 1 hour under nitrogen
  3. customThe solvent was evaporated

Sources & evidence

ORD record
ord-2bc6d53f28e94df98b2ded334b3783cd
Source dataset
uspto-grants-2003_09
Patent number
US06613876B1

Reaction notes

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