Hydrochloric Acid → HCID 11225270, compound

Participants

Reaction Steps

The crude oil of the N-Cbz-Pro-Ala-Gly-Pro-OCH3 (5g, 12 mmol) was dissolved in methanol (20 ml) in a round bottom flask. The flask was placed in an ambient temperature water bath. 1 N Sodium hydroxide solution (12 ml) was added cautiously. The solution was stirred for 3.5 hours after which time 1 N HCl solution (12 ml) was added. The solution was concentrated on the roto-evaporator and a few more drops of 1 N HCl was added until the pH is approximately 1.5 with pH paper. The water was removed with the vacuum pump to give an oil, which was recrystalized slowly from ethanol.

Provenance & Evidence