HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → HCID 12085190, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | (3S)-3-phenylbutanoic acid | HCID 852991 | — |
| Catalyst | Rhodium | HCID 23948 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 12085190 | HCID 12085190 | — |
Reaction Steps
(S)-3-phenylbutyric acid was hydrogenated using Rh/C in MeOH at 60 psi and 60° C. for 3.2 hours. The reduced product was then converted to the title acid chloride by treating with 1 eq of oxalyl chloride, and a catalytic amount of DMF, in toluene for 90 minutes, followed by evaporation of the volatile materials.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06613880B2 |
| Source dataset | uspto-grants-2003_09 |
| ORD ID | ord-e425d4f156254adc9d08a4f60024b1b6 |
| Source note | uspto-grants-2003_09 |