反应详情

Following General Procedure A, 7-methoxy-4,4,6-trimethyl-3,4-dihydro-2H-naphthalen-1-one (Compound 6, 0.5 g, 2.3 mmol) was reacted with a solution of 3M EtMgBr (2.3 mL, 6.9 mmol), and the crude product was purified by flash chromatography (hexane:ethyl acetate=4:1) to give 0.33 g (63%) of the title compound as a clear oil. PNMR (300 MHz, CDCl3) δ 1.32 (t, 3H, J=6.3 Hz), 1.38 (s, 6H), 2.32 (d, 2H, J=4.5 Hz), 2.42 (s, 3H), 2.65 (m, 2H), 3.98 (s, 3H), 5.88 (t, 1H, J=2.5 Hz), 6.96 (s, 1H), 7.28 (s, 1H).

1. customthe crude product was purified by flash chromatography (hexane:ethyl acetate=4:1)