Acetaldehyde → HCID 10180392, compound

HRID 1166646Notes

Reaction equation

[C:1]([C:5]1[C:14]2[CH:13]=[C:12]([NH:15][C:16]3[CH:26]=[CH:25][C:19]([C:20]([O:22][CH2:23][CH3:24])=[O:21])=[CH:18][CH:17]=3)[C:11]([CH3:27])=[CH:10][C:9]=2[C:8]([CH3:29])([CH3:28])[CH2:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[CH:30](=O)[CH3:31]>>[CH2:30]([N:15]([C:12]1[C:11]([CH3:27])=[CH:10][C:9]2[C:8]([CH3:28])([CH3:29])[CH2:7][CH:6]=[C:5]([C:1]([CH3:4])([CH3:3])[CH3:2])[C:14]=2[CH:13]=1)[C:16]1[CH:17]=[CH:18][C:19]([C:20]([O:22][CH2:23][CH3:24])=[O:21])=[CH:25][CH:26]=1)[CH3:31]

Participants

Reactant 2

HCID 177Acetaldehyde

HCID 10293873HCID 10293873, compound2×

Product 1

HCID 10180392HCID 10180392, compoundYield 77.3%

Procedure

Following General Procedure D, ethyl 4-[(8-tert-butyl-3,5,5-trimethyl-5,6-dihydronaphthalen-2yl)amino]benzoate (Compound 18, 0.14 g, 0.37 mmol) was reacted with acetaldehyde (0.40 mL, 7.4 mmol) to give 0.12 g (75%) of the title compound as a light yellow solid.

Sources & evidence

ORD record: ord-644f50d56cbf4d66858e53dc87a034fb
Source dataset: uspto-grants-2003_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06613917B1

Reaction notes

Loading…