HCID 22218197, compound → HCID 22218314, compound

HRID 1166652Notes

Reaction equation

HRID 1166652 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[CH3:13])[C:9](=O)[CH2:8][CH2:7][C:6]2([CH3:16])[CH3:15].[CH:17]([Mg]Cl)([CH3:19])[CH3:18]>>[CH:17]([C:9]1[C:10]2[C:5](=[CH:4][C:3]([O:2][CH3:1])=[C:12]([CH3:13])[CH:11]=2)[C:6]([CH3:16])([CH3:15])[CH2:7][CH:8]=1)([CH3:19])[CH3:18]

Participants

3

Reactant 2

HCID 22218197HCID 22218197, compound2×HCID 178418918HCID 178418918, compound

Product 1

HCID 22218314HCID 22218314, compoundYield 53%

Procedure

Following General Procedure F, 6-methoxy-4,4,7-trimethyl-3,4-dihydro-2H-naphtalen-1-one (compound 30) (1.5 g, 6.9 mmol) was reacted with a solution of 2M isopropylmagnesiumchloride (17 mL, 34.5 mmol), and the crude product was purified by flash column (hexane:ethyl acetate=4:1) to give 0.88 g (53%) of the title product as a yellow oil.

Workup

  1. customthe crude product was purified by flash column (hexane:ethyl acetate=4:1)

Sources & evidence

ORD record
ord-625e5f2204124abcb61d63a4c740520a
Source dataset
uspto-grants-2003_09
Patent number
US06613917B1

Reaction notes

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