Cyclopropanecarboxaldehyde → HCID 10294606, compound

HRID 1166656Notes

Reaction equation

HRID 1166656 reaction equation
[CH3:1][C:2]1[C:3]([NH:15][C:16]2[CH:26]=[CH:25][C:19]([C:20]([O:22][CH2:23][CH3:24])=[O:21])=[CH:18][CH:17]=2)=[CH:4][C:5]2[C:6]([CH3:14])([CH3:13])[CH2:7][CH:8]=[C:9]([CH3:12])[C:10]=2[CH:11]=1.[CH:27]1([CH:30]=O)[CH2:29][CH2:28]1>>[CH:27]1([CH2:30][N:15]([C:3]2[C:2]([CH3:1])=[CH:11][C:10]3[C:9]([CH3:12])=[CH:8][CH2:7][C:6]([CH3:14])([CH3:13])[C:5]=3[CH:4]=2)[C:16]2[CH:17]=[CH:18][C:19]([C:20]([O:22][CH2:23][CH3:24])=[O:21])=[CH:25][CH:26]=2)[CH2:29][CH2:28]1

Participants

3

Reactant 2

HCID 123114CyclopropanecarboxaldehydeHCID 22218329HCID 22218329, compound2×

Product 1

HCID 10294606HCID 10294606, compoundYield 43.4%

Procedure

Following General Procedure D, ethyl 4-(3,5,8,8-tetramethyl-7,8-dihydronaphthalen-2-ylamino)benzoate (Compound 39, 0.085 g, 0.24 mmol) was reacted with cyclopropane carboxaldehyde (180 μL, 2.4 mmol) to give 0.042 g (43%) of the title compound as a clear oil.

Sources & evidence

ORD record
ord-20ec2ad3e2a7438cb973c3a95c1b984c
Source dataset
uspto-grants-2003_09
Patent number
US06613917B1

Reaction notes

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