Acetaldehyde → HCID 22218233, compound

HRID 1166657Notes

Reaction equation

[CH2:1]([C:3]1[C:4]2[CH:5]=[C:6]([CH3:27])[C:7]([NH:15][C:16]3[CH:26]=[CH:25][C:19]([C:20]([O:22][CH2:23][CH3:24])=[O:21])=[CH:18][CH:17]=3)=[CH:8][C:9]=2[C:10]([CH3:14])([CH3:13])[CH2:11][CH:12]=1)[CH3:2].[CH:28](=O)[CH3:29]>>[CH2:28]([N:15]([C:7]1[C:6]([CH3:27])=[CH:5][C:4]2[C:3]([CH2:1][CH3:2])=[CH:12][CH2:11][C:10]([CH3:13])([CH3:14])[C:9]=2[CH:8]=1)[C:16]1[CH:17]=[CH:18][C:19]([C:20]([O:22][CH2:23][CH3:24])=[O:21])=[CH:25][CH:26]=1)[CH3:29]

Participants

Reactant 2

HCID 177Acetaldehyde

HCID 22218200HCID 22218200, compound

Product 1

HCID 22218233HCID 22218233, compoundYield 63%

Procedure

Following General Procedure D, ethyl 4-(5-ethyl-3,8,8-tetramethyl-7,8-dihydronaphthalen-2-ylamino)benzoate (Compound 55, 0.37 g, 1.0 mmol) was reacted with acetaldehyde (0.56 mL, 10.0 mmol) to give 0.25 g (63%) of the title compound as a clear oil.

Sources & evidence

ORD record: ord-7f662ca9495c4562bc52f24aabba74c6
Source dataset: uspto-grants-2003_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06613917B1

Reaction notes

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