Formaldehyde → HCID 22218268, compound

HRID 1166658Notes

Reaction equation

HRID 1166658 reaction equation
[CH:1]([C:4]1[C:5]2[CH:6]=[C:7]([CH3:28])[C:8]([NH:16][C:17]3[CH:27]=[CH:26][C:20]([C:21]([O:23][CH2:24][CH3:25])=[O:22])=[CH:19][CH:18]=3)=[CH:9][C:10]=2[C:11]([CH3:15])([CH3:14])[CH2:12][CH:13]=1)([CH3:3])[CH3:2].[CH2:29]=O>>[CH3:29][N:16]([C:8]1[C:7]([CH3:28])=[CH:6][C:5]2[C:4]([CH:1]([CH3:3])[CH3:2])=[CH:13][CH2:12][C:11]([CH3:14])([CH3:15])[C:10]=2[CH:9]=1)[C:17]1[CH:18]=[CH:19][C:20]([C:21]([O:23][CH2:24][CH3:25])=[O:22])=[CH:26][CH:27]=1

Participants

3

Reactant 2

HCID 712FormaldehydeHCID 22218256HCID 22218256, compound2×

Product 1

HCID 22218268HCID 22218268, compoundYield 100%

Procedure

Following General Procedure D, ethyl 4-(5-isopropyl-3,8,8-trimethyl-7,8-dihydronaphthalen-2-ylamino)benzoate (Compound 48, 0.10 g, 0.26 mmol) was reacted with an aqueous solution of formaldehyde 37% (0.20 mL, 2.6 mmol) to give 0.10 g (100%) of the title compound as a clear oil.

Sources & evidence

ORD record
ord-a12c2978fa64464faae0d7c1eb1aaaf8
Source dataset
uspto-grants-2003_09
Patent number
US06613917B1

Reaction notes

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