Acetaldehyde → HCID 22218292, compound

HRID 1166661Notes

Reaction equation

[C:1]([C:5]1[C:6]2[CH:7]=[C:8]([CH3:29])[C:9]([NH:17][C:18]3[CH:28]=[CH:27][C:21]([C:22]([O:24][CH2:25][CH3:26])=[O:23])=[CH:20][CH:19]=3)=[CH:10][C:11]=2[C:12]([CH3:16])([CH3:15])[CH2:13][CH:14]=1)([CH3:4])([CH3:3])[CH3:2].[CH:30](=O)[CH3:31]>>[CH2:30]([N:17]([C:9]1[C:8]([CH3:29])=[CH:7][C:6]2[C:5]([C:1]([CH3:2])([CH3:3])[CH3:4])=[CH:14][CH2:13][C:12]([CH3:15])([CH3:16])[C:11]=2[CH:10]=1)[C:18]1[CH:19]=[CH:20][C:21]([C:22]([O:24][CH2:25][CH3:26])=[O:23])=[CH:27][CH:28]=1)[CH3:31]

Participants

Reactant 2

HCID 177Acetaldehyde

HCID 22218207HCID 22218207, compound2×

Product 1

HCID 22218292HCID 22218292, compoundYield 62%

Procedure

Following General Procedure D, ethyl 4-[(5-tert-butyl-3,8,8-trimethyl-7,8-dihydronaphthalen-2-yl)amino]benzoate (Compound 56, 0.019 g, 0.05 mmol) was reacted with acetaldehyde (0.030 mL, 0.5 mmol) to give 0.013 g (62%) of the title compound as a clear oil.

Sources & evidence

ORD record: ord-f9ec1f29d1744333bc394c4748ad8e46
Source dataset: uspto-grants-2003_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06613917B1

Reaction notes

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