HCID 13412254, compound → HCID 22218195, compound

HRID 1166670Notes

Reaction equation

HRID 1166670 reaction equation
[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([CH3:14])([CH3:13])[CH2:7][CH2:8][C:9]2=O)=[CH:4][C:3]=1[O:15][CH3:16].[CH3:17][Mg+].[Br-]>>[Br:1][C:2]1[CH:11]=[C:10]2[C:5](=[CH:4][C:3]=1[O:15][CH3:16])[C:6]([CH3:14])([CH3:13])[CH2:7][CH:8]=[C:9]2[CH3:17]

Participants

3

Reactant 2

HCID 13412254HCID 13412254, compoundHCID 178418689HCID 178418689, compound

Product 1

HCID 22218195HCID 22218195, compoundYield 94%

Procedure

Following General Procedure A 7-bromo-6-methoxy-4,4-dimethyl-3,4-dihydro-2H-naphthanlen-1-one (Compound 92,1.0 g, 3.5 mmol) was reacted with MeMgBr to give 0.93 g (94%) of the title compound as a yellow solid.

Sources & evidence

ORD record
ord-e27ce62bc4854b1a9188fc6834139e85
Source dataset
uspto-grants-2003_09
Patent number
US06613917B1

Reaction notes

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