Acetaldehyde → HCID 22218234, compound

HRID 1166687Notes

Reaction equation

[CH:1]([C:4]1[C:13]2[CH:12]=[C:11]([NH:14][C:15]3[CH:25]=[CH:24][C:18]([C:19]([O:21][CH2:22][CH3:23])=[O:20])=[CH:17][CH:16]=3)[C:10]([O:26][CH2:27][CH2:28][CH3:29])=[CH:9][C:8]=2[C:7]([CH3:31])([CH3:30])[CH2:6][CH:5]=1)([CH3:3])[CH3:2].[CH:32](=O)[CH3:33]>>[CH2:32]([N:14]([C:11]1[C:10]([O:26][CH2:27][CH2:28][CH3:29])=[CH:9][C:8]2[C:7]([CH3:31])([CH3:30])[CH2:6][CH:5]=[C:4]([CH:1]([CH3:3])[CH3:2])[C:13]=2[CH:12]=1)[C:15]1[CH:16]=[CH:17][C:18]([C:19]([O:21][CH2:22][CH3:23])=[O:20])=[CH:24][CH:25]=1)[CH3:33]

Participants

Reactant 2

HCID 177Acetaldehyde

HCID 22218254HCID 22218254, compound2×

Product 1

HCID 22218234HCID 22218234, compoundYield 70%

Procedure

Following General Procedure D, ethyl 4-(8-isopropyl-5,5-dimethyl-3-n-propoxy-5,6-dihydronaphthalen-2-ylamino)benzoate (Compound 117, 0.18 g, 0.43 mmol) was reacted with acetaldehyde to afford 0.14 g (70%) of the title compound as a yellow oil.

Sources & evidence

ORD record: ord-765ea55f147746c3a959ae1e66fcadaa
Source dataset: uspto-grants-2003_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06613917B1

Reaction notes

Loading…