HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → HCID 67483598, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Hydrazine | HCID 9321 | — |
| Reactant | Ethyl 5-hydroxy-1H-indole-2-carboxylate | HCID 90677 | — |
| Product | HCID 67483598 | HCID 67483598 | 85% |
Reaction Steps
To a sample of ethyl 5-hydroxyindole-2-carboxylate (5 g, 24 mmol), dissolved in ethanol (250 mL) was added hydrazine (4 mL, 121 mmol). The reaction was refluxed overnight under nitrogen. Upon cooling the reaction vessel, the desired product crystallized. The white solid was isolated by filtration. Recrystallization from hot ethanol gave the 5-hydroxyindole-3-carboxylic acid hydrazide in 85% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06613942B1 |
| Source dataset | uspto-grants-2003_09 |
| ORD ID | ord-471d6f2d684b40ecad26a488b1e6f365 |
| Source note | uspto-grants-2003_09 |