HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1166722Generated: October 26, 2026
Potassium Carbonate → 4-(2-Tetrahydropyranylmethoxy)-1-naphthaldehyde
https://huagongshe.com/reaction/1166722
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-(Bromomethyl)tetrahydro-2H-pyran | HCID 141917 | — |
| Reactant | 4-Hydroxy-1-naphthaldehyde | HCID 344290 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 4-(2-Tetrahydropyranylmethoxy)-1-naphthaldehyde | HCID 22999259 | — |
Reaction Steps
A mixture of 4-hydroxynaphthaldehyde (1 g, 5.8 mmol), 2-bromomethyl tetrahydropyran (1 g, 5.8 mmol) and powdered K2CO3 (1.2 g, 8.7 mmol) in dimethyl formamide was stirred at 60° C. overnight. The mixture was taken up in water and ethyl acetate. The organic layer was separated and washed with water, brine, dried over MgSO4, filtered, and concentrated. The product was purified by silica gel column chromatography using ethyl acetate/hexane.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06613942B1 |
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| Source dataset | uspto-grants-2003_09 |
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| ORD ID | ord-6ae341a9fe754b399a0839803941ce30 |
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| Source note | uspto-grants-2003_09 |
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