HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 3-Chloro-4-hydroxybenzohydrazide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-Chloro-4-hydroxybenzohydrazide | HCID 10954268 | — |
Reaction Steps
The above resin (3.0 g) was suspended in CH2Cl2 (20 mL) and 1-hydroxybenzotriazole (0.6 g), N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide, hydrochloride (0.9 g) and DMF (10 mL) were added. The mixture was shaken at room temperature for 45 minutes, hydrazine hydrate (300 μL) was added, and the mixture was shaken overnight at room temperature. The resin was successively washed with DMF (3×20 mL) and CH2Cl2 (3×20 mL) to afford resin bound 3-chloro-4-hydroxybenzoic acid hydrazide (Resin—[Building block 1]).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06613942B1 |
| Source dataset | uspto-grants-2003_09 |
| ORD ID | ord-3ccee833de9a452bb248eda4a4b74393 |
| Source note | uspto-grants-2003_09 |