反应详情

To a suspension of 5-bromo-1-naphthylcarboxylic acid (5 g, 20 mmol) in 200 mL anhydrous MeOH was added 5 mL concentrated H2SO4 and refluxed overnight. The reaction was cooled to room temperature and concentrated to one-third the volume. The residue was diluted with water and extracted with diethyl ether. The organic layer was separated and washed with water (2×), dried over MgSO4, and concentrated. Silica gel column chromatography using hexane/ethyl acetate (2/11) gave 4.91 g (92%) of the product.

1. temperaturerefluxed overnight
2. concentrationconcentrated to one-third the volume
3. additionThe residue was diluted with water
4. extractionextracted with diethyl ether
5. customThe organic layer was separated
6. washwashed with water (2×)
7. dry with materialdried over MgSO4
8. concentrationconcentrated