Hydrochloric Acid → HCID 22999255, compound

Participants

Reaction Steps

To a solution of 1-[4-(5,5-Dimethyl-1,3-dioxan-2-yl)-1-naphthyl]-3-methyl-1-butanol (1.76 g, 5.35 mmol) in THF (10 mL) was added water (1 mL) and conc. HCl (1 mL). The solution was stirred at room temp. for 16 hours, diluted with NaHCO3-solution (20 mL), and extracted with ether (3×30 mL). The combined organic extracts were dried and concentrated. Flash chromatography (silicagel, hexanes:ethyl acetate, 4:1) provided 900 mg (70%) colorless oil.

Provenance & Evidence