5-Bromothiophene-2-sulfonyl chloride → N-(4-Bromo-3-methyl-5-isoxazolyl)-5-bromothiophene-2-sulfonamide

HRID 1166823Notes

Reaction equation

HRID 1166823 reaction equation
[NH2:1][C:2]1[O:6][N:5]=[C:4]([CH3:7])[C:3]=1[Br:8].[Br:9][C:10]1[S:14][C:13]([S:15](Cl)(=[O:17])=[O:16])=[CH:12][CH:11]=1>>[Br:8][C:3]1[C:4]([CH3:7])=[N:5][O:6][C:2]=1[NH:1][S:15]([C:13]1[S:14][C:10]([Br:9])=[CH:11][CH:12]=1)(=[O:17])=[O:16]

Participants

3

Reactant 2

HCID 27339245-Bromothiophene-2-sulfonyl chlorideHCID 104875194-Bromo-3-methylisoxazol-5-amine

Product 1

HCID 23445555N-(4-Bromo-3-methyl-5-isoxazolyl)-5-bromothiophene-2-sulfonamideYield 30%

Procedure

N-(4-Bromo-3-methyl-5-isoxazolyl)-5-bromothiophene-2-sulfonamide was prepared in the same manner as described in Example 2 from 5-amino-4-bromo-3-methylisoxazole and 5-bromothiophene-2-sulfonyl chloride in 30% yield. Purification was achieved by recrystallization from ethyl acetate/hexanes to give a crystalline solid, m.p. 240° C. (dec).

Workup

  1. customPurification
  2. customwas achieved by recrystallization from ethyl acetate/hexanes
  3. customto give a crystalline solid, m.p. 240° C. (dec)

Sources & evidence

ORD record
ord-8163f4a071d6427da04f0068b6f970eb
Source dataset
uspto-grants-2003_09
Patent number
US06613804B2

Reaction notes

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