4-Bromo-3-methylisoxazol-5-amine → HCID 22998417, compound

HRID 1166878Notes

Reaction equation

HRID 1166878 reaction equation
[NH2:1][C:2]1[O:6][N:5]=[C:4]([CH3:7])[C:3]=1[Br:8].[CH2:9]([C:17]1[CH:21]=[CH:20][S:19][C:18]=1[S:22](Cl)(=[O:24])=[O:23])[CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>>[Br:8][C:3]1[C:4]([CH3:7])=[N:5][O:6][C:2]=1[NH:1][S:22]([C:18]1[S:19][CH:20]=[CH:21][C:17]=1[CH2:9][CH2:10][C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1)(=[O:23])=[O:24]

Participants

3

Reactant 2

HCID 104875194-Bromo-3-methylisoxazol-5-amineHCID 22998403HCID 22998403, compound

Product 1

HCID 22998417HCID 22998417, compoundYield 48%

Procedure

N-(4-bromo-3-methyl-5-isoxazolyl)-3-phenethylthiophene-2-sulfonamide was prepared in the same manner as described in Example 2 from 5-amino-4-bromo-3-methylisoxazole and 3-phenethyl-2-thiophenesulfonyl chloride in 48% yield. This was purified by HPLC (5% CH3CN to 100% CH3CN over 30 min.) to give a solid.

Workup

  1. customThis was purified by HPLC (5% CH3CN to 100% CH3CN over 30 min.)
  2. customto give a solid

Sources & evidence

ORD record
ord-92a0e50cf0bd47059207b5f5d67d11a6
Source dataset
uspto-grants-2003_09
Patent number
US06613804B2

Reaction notes

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