4-Bromo-3-methylisoxazol-5-amine → HCID 23445254, compound

HRID 1166941Notes

Reaction equation

HRID 1166941 reaction equation
Cl[S:2]([C:5]1[S:6][CH:7]=[CH:8][C:9]=1[CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)(=[O:4])=[O:3].[NH2:17][C:18]1[O:22][N:21]=[C:20]([CH3:23])[C:19]=1[Br:24]>>[Br:24][C:19]1[C:20]([CH3:23])=[N:21][O:22][C:18]=1[NH:17][S:2]([C:5]1[S:6][CH:7]=[CH:8][C:9]=1[CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)(=[O:4])=[O:3]

Participants

3

Reactant 2

HCID 104875194-Bromo-3-methylisoxazol-5-amineHCID 22998485HCID 22998485, compound

Product 1

HCID 23445254HCID 23445254, compoundYield 24%

Procedure

N-(4-bromo-3-methyl-5-isoxazolyl)-3-benzylthiophene-2-sulfonamide was prepared in the same manner as described in Example 2 by reacting 2-chlorosulfonyl-3-benzylthiophene with 5-amino-4-bromo-3-methylisoxazole resulting in a 24% yield, m.p. 180-183° C.

Sources & evidence

ORD record
ord-1fe90a044cda494882846d874fbbfd5d
Source dataset
uspto-grants-2003_09
Patent number
US06613804B2

Reaction notes

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