4-Bromo-3-methylisoxazol-5-amine → HCID 23445229, compound

HRID 1166948Notes

Reaction equation

HRID 1166948 reaction equation
Cl[S:2]([C:5]1[S:6][CH:7]=[CH:8][C:9]=1[C:10]1[CH:15]=[CH:14][C:13]2[O:16][CH2:17][O:18][C:12]=2[CH:11]=1)(=[O:4])=[O:3].[NH2:19][C:20]1[O:24][N:23]=[C:22]([CH3:25])[C:21]=1[Br:26]>>[Br:26][C:21]1[C:22]([CH3:25])=[N:23][O:24][C:20]=1[NH:19][S:2]([C:5]1[S:6][CH:7]=[CH:8][C:9]=1[C:10]1[CH:15]=[CH:14][C:13]2[O:16][CH2:17][O:18][C:12]=2[CH:11]=1)(=[O:4])=[O:3]

Participants

3

Reactant 2

HCID 104875194-Bromo-3-methylisoxazol-5-amineHCID 23445411HCID 23445411, compound

Product 1

HCID 23445229HCID 23445229, compoundYield 60%

Procedure

N-(4-bromo-3-methyl-5-isoxazolyl)-3-[3,4-(methylenedioxy)phenyl]thiophene-2-sulfonamide was prepared in the same manner as described in Example 1 by reaction of 2-chlorosulfonyl-3-[3,4-(methylenedioxy)phenyl]thiophene with 5-amino-4-bromo-3-methylisoxazole resulting in a 60% yield, m.p. 183-186° C.

Sources & evidence

ORD record
ord-29338caba9ce4703b2897cc86282d041
Source dataset
uspto-grants-2003_09
Patent number
US06613804B2

Reaction notes

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