HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Trifluoromethyl)phenylboronic acid → N-{5-[4-(trifluoromethyl)phenyl]thiophene-2-sulfonyl}pyrrole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Trifluoromethyl)phenylboronic acid | HCID 2734389 | — |
| Reactant | N-(5-bromothiophenesulfonyl)pyrrole | HCID 23445587 | — |
| Product | N-{5-[4-(trifluoromethyl)phenyl]thiophene-2-sulfonyl}pyrrole | HCID 22998451 | 75% |
Reaction Steps
N-{5-[4-(trifluoromethyl)phenyl]thiophene-2-sulfonyl}pyrrole was prepared in the same manner as described in Example 32C using 4-trifluoromethylbenzene boronic acid and N-(5-bromothiophene sulfonyl)pyrrole. Purification by column chromatography using 2% ethyl acetate/hexanes gave the pure sulfonamide as a white powder in 75% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06613804B2 |
| Source dataset | uspto-grants-2003_09 |
| ORD ID | ord-af24c1913aad43beb8e8e3ca1c23881f |
| Source note | uspto-grants-2003_09 |