HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 4-bromobenzoate → Methyl 4-(thiophen-2-yl)benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 4-bromobenzoate | HCID 12081 | — |
| Reactant | 2-Thiopheneboronic acid | HCID 2733960 | — |
| Product | Methyl 4-(thiophen-2-yl)benzoate | HCID 3697617 | 65% |
Reaction Steps
2-(4-methoxycarbonylphenyl)thiophene was prepared in the same manner as described in Example 32C from thiophene-2-boronic acid (1.0 g, 7.81 mmol) and methyl-4-bromobenzoate (1.68 g, 7.81 mmol). Purification by column chromatography using 2% ethyl acetate/hexanes gave 1.1 g of 2-(4-methoxycarbonylphenyl)thiophene as a white solid (65% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06613804B2 |
| Source dataset | uspto-grants-2003_09 |
| ORD ID | ord-8cb4e9231cbc4e36b73769795f3f05f4 |
| Source note | uspto-grants-2003_09 |