反应详情

N-(4-bromo-5-methyl-3-isoxazolyl)-4-biphenylsulfonamide was prepared, using the method in Example 193b, from 3-amino-4-bromo-5-methylisoxazole and 4-biphenylsulfonyl chloride in 5% yield. The crude product was purified by column chromatography. After recrystallization from ethyl acetate/hexanes, N-(4-bromo-5-methyl-3-isoxazolyl)-4-biphenylsulfonamide (m.p. 154-156° C.) was obtained in 51% yield.

1. customN-(4-bromo-5-methyl-3-isoxazolyl)-4-biphenylsulfonamide was prepared
2. customThe crude product was purified by column chromatography
3. customAfter recrystallization from ethyl acetate/hexanes