(3-Methoxyphenyl)boronic acid → N-(3-methyl-5-isoxazolyl)-4-(3-methoxyphenyl)benzenesulfonamide

HRID 1167026Notes

Reaction equation

HRID 1167026 reaction equation
[CH3:1][C:2]1[CH:6]=[C:5]([NH:7][S:8]([C:11]2[CH:16]=[CH:15][C:14](Br)=[CH:13][CH:12]=2)(=[O:10])=[O:9])[O:4][N:3]=1.[CH3:18][O:19][C:20]1[CH:21]=[C:22](B(O)O)[CH:23]=[CH:24][CH:25]=1>>[CH3:1][C:2]1[CH:6]=[C:5]([NH:7][S:8]([C:11]2[CH:16]=[CH:15][C:14]([C:24]3[CH:23]=[CH:22][CH:21]=[C:20]([O:19][CH3:18])[CH:25]=3)=[CH:13][CH:12]=2)(=[O:10])=[O:9])[O:4][N:3]=1

Participants

3

Reactant 2

HCID 2734370(3-Methoxyphenyl)boronic acidHCID 15453181N-(3-methyl-5-isoxazolyl)-4-bromobenzenesulfonamide

Product 1

HCID 15453194N-(3-methyl-5-isoxazolyl)-4-(3-methoxyphenyl)benzenesulfonamideYield 77%

Procedure

N-(3-methyl-5-isoxazolyl)-4-(3-methoxyphenyl)benzenesulfonamide was prepared in the same manner as described in Example 206b, using N-(3-methyl-5-isoxazolyl)-4-bromobenzenesulfonamide (Example 206a) and 3-methoxybenzeneboronic acid resulting in a 77% yield.

Sources & evidence

ORD record
ord-f66cba1b1eb44dd4b4fc73181fd5f2d6
Source dataset
uspto-grants-2003_09
Patent number
US06613804B2

Reaction notes

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