HRID1167088

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID887

Methanol

CH4O

HCID962

Water

H2O

HCID10340

Carbonic acid sodium salt (1:2)

CNa2O3

结构：CC(=O)OC[C@@H]1O[C@H](n2c(NC(C)C)nc3c(Cl)cccc32)[C@@H](OC(C)=O)[C@H]1OC(C)=O

HCID57293610

未命名化合物

PRODUCTS

生成物

结构：CC(C)Nc1nc2c(Cl)cccc2n1[C@H]1O[C@@H](CO)[C@H](O)[C@@H]1O

HCID57124973

未命名化合物

收率 68.4%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

4-Chloro-2-(isopropylamino)-1-(2,3,5-tri-O-acetyl-beta-L-ribofuranosyl)-1H-benzimidazole (2.24 g, 4.79 mmol), sodium carbonate (0.67 g, 6.32 mmol), water (7 mL), methanol (14 mL) and ethanol (20 mL) were used according to general procedure III. The product was purified by silica gel chromatography using 10:1 dichloromethane/methanol to afford 1.12 g (68%) of a white solid: m.p. 225-227° C. Anal. calcd for C15H20ClN3O4: C, 52.77; H, 5.91; N, 12.32. Found: C, 52.79; H, 5.96; N, 12.25.

WORKUP

后处理

customThe product was purified by silica gel chromatography