HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclohexene → N-(Piperidin-4-yl)-4'-(trifluoromethyl)-biphenyl-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclohexene | HCID 8079 | — |
| Reactant | 1-Benzyl-4-(4'-trifluoromethylbiphenyl-2-carbonylamino)piperidine | HCID 22995692 | — |
| Catalyst | Palladium hydroxide | HCID 9942167 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | N-(Piperidin-4-yl)-4'-(trifluoromethyl)-biphenyl-2-carboxamide | HCID 9928271 | — |
Reaction Steps
31.6 g (0.072 mol) of 4′-trifluoromethyl-biphenyl-2-carboxylic acid-(1-benzyl-piperidin-4-yl)-amide are dissolved in 180 ml ethanol and 180 ml methanol, mixed with 84 ml (0.83 mol) of cyclohexene and 6.53 g of palladium hydroxide (20% on charcoal) and refluxed for four hours. The hot reaction mixture is filtered through kieselguhr and the reaction mixture is concentrated by rotary evaporation.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06617325B1 |
| Source dataset | uspto-grants-2003_09 |
| ORD ID | ord-106d94eed4db4e3c9eaca0aec285400e |
| Source note | uspto-grants-2003_09 |