2-Bromo-3-fluorobenzonitrile → 6,2'-Difluoro-5'-nitrobiphenyl-2-carbonitrile

Participants

Reaction Steps

2-Bromo-3-fluorobenzonitrile (2.50 g, 12.5 mmol) was coupled to 2-(2-fluoro-5-nitrophenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane as described in Example 1 to give 6,2′-difluoro-5′-nitrobiphenyl-2-carbonitrile as a black solid: 1H NMR (360 MHz, CDCl3) δ 7.40-7.44 (1H, m), 7.47-7.52 (1H, m), 7.59-7.67 (2H, m), 8.37-8.44 (2H, m).

Provenance & Evidence