Phosphorus oxychloride → HCID 74014582, compound

Participants

Reaction Steps

N-(5-Iodo-4-trifluoromethylthiazol-2-yl)-3-trifluoromethylbenzamide (9.3 g was mixed with phosphorous pentachloride (4.2 g) and phosphorous oxychloride (25 ml) and the mixture was refluxed for 7 hr. The excess phosphorous oxychloride was removed under reduced pressure and the residue was mixed with cold water then extracted with chloroform. The extract was dried over anhydrous magnesium sulfate and the solvent was removed under reduced pressure then the residue was recrystallized from chloroform-n-hexane to give N-(5-iodo-4-trifluoromethylthiazol-2-yl)-3-trifluoromethylbenzimidoyl chloride as yellow needles (8.5 g), m. p. 136-137° C.

Provenance & Evidence