Phosphorus pentachloride → HCID 74014581, compound

Participants

Reaction Steps

N-(5-Chloro-4-trifluoromethylthiazol-2-yl)-3-chlorobenzamide (15.5 g was mixed with phosphorous pentachloride (9.5 g) and phosphorous oxychloride (60 ml) and the mixture was refluxed for 12 hr. The excess phosphorous oxychloride was removed under reduced pressure and the residue was mixed with cold water then extracted with chloroform. The extract was dried over anhydrous magnesium sulfate and the solvent was removed under reduced pressure then the residue was recrystallized from n-hexane to give N-(5-chloro-4-trifluoromethylthiazol-2-yl)-3-chlorobenzimidoyl chloride; as pale brown needles (11.0 g), m. p. 89-90° C.

Provenance & Evidence