Hydrochloric Acid → (+)-2-phenyl-3-methyl-8-(1-(R)-[2-(R)-methylpiperidino]-2-hydroxyethyl)quinoline hydrochloride

Participants

Reaction Steps

8.3 ml of a 0.1N hydrochloric acid solution are added to a solution of 0.3 g (0.832 mmol) of (+)-2-phenyl-3-methyl-8-(1-(R)-[2-(R)-methylpiperidino]-2-hydroxyethyl)quinoline in 3 ml of methanol. The solvents are evaporated and the salt obtained is dissolved in 10 ml of water. The solution is filtered, frozen with a bath of dry ice in acetone, and lyophilized overnight to provide 0.33 g of (+)-2-phenyl-3-methyl-8-(1-(R)-[2-(R)-methylpiperidino]-2-hydroxyethyl)quinoline hydrochloride in the form of a white solid; M.p.=68° C. (Yield: quantitative)

Provenance & Evidence