反应详情

温度

135 °C

64 g (397 mmol) of 8-hydroxyquinoline N-oxide, 550 ml of acetic anhydride and 40 ml of acetic acid are placed in a 1 l round-bottomed flask. The reaction mixture is heated at reflux (135° C.) for 24 h, 40 ml of acetic acid are then again added and heating is continued for 1 h 30. The reaction mixture is allowed to return to ambient temperature and 400 ml of toluene are added. A precipitate appears and is filtered off. A further 400 ml of toluene are added and filtration is carried out. The precipitate is washed with 200 ml of ethyl ether and is dried in a desiccator under vacuum over phosphorus pentoxide to provide to provide 70.5 g of 2-acetoxy-8-hydroxyquinoline in the form of a brown solid. (Yield: 88%)

1. temperatureThe reaction mixture is heated
2. temperatureheating
3. customto return to ambient temperature
4. filtrationis filtered off
5. additionA further 400 ml of toluene are added
6. filtrationfiltration
7. washThe precipitate is washed with 200 ml of ethyl ether
8. dry with materialis dried in a desiccator under vacuum over phosphorus pentoxide
9. customto provide