Dimethyl Sulfoxide → HCID 434493, compound

Participants

Reaction Conditions

Reaction Steps

(±)-3-(4-trifluoromethylphenyl)-8-azabicyclo[3.2.1]oct-2-ene in the form of a free amine (1 mg) was dissolved in anhydrous dimethyl sulphoxide (DMSO; 300 ml), and then reacted with [11C]-methyl iodide and heated for 5 min at 130° C. The resulting N-[11C]-methyl labelled [11C]-compound was subsequently purified by HPLC. Removal of the HPLC solvent was achieved by heating the [11C]-labelled (±)8-methyl-3-(4-trifluoromethylphenyl)-8-azabicyclo[3.2.1]oct-2-ene containing fraction under reduced pressure. The labelled product was then formulated in saline or water (10 ml) and passed over a 0.22 mm membrane filter into a sterile vial.

Provenance & Evidence