Ammonia → HCID 21356619, compound

Participants

Reaction Steps

To a stirred solution of Example 59 (203 mg, 0.43 mmol) in THF (15 ml) was added 1N HCl (10 ml). The reaction was allowed to stir at ambient temperature for 18 hours. The reaction was basified with ammonia solution until aqueous layer was pH12. The reaction was extracted with EtOAc and the combined organic phases were washed with sat NaCl and then dried over MgSO4 and evaporated under reduced pressure. The resulting yellow oil was triturated with ether to give the title compound as a pale yellow solid (167 mg, 90%). MS: ESP+ (M+H)+=434.

Provenance & Evidence