(5R)-3-[3-fluoro-4-(3-hydroxyazetidin-1-yl)phenyl]-5-(isoxazol-3-yloxymethyl)oxazolidin-2-one → 3-(3-Fluoro-4-(2-methyl-imidazol-1-yl)phenyl)-5(r)-(isoxazol-3-yloxymethyl)oxazolidin-2-one

Participants

Reaction Steps

Using essentially the same procedure as for the intermediate of Example 65, but starting with 3-(3-fluoro-4-(2-methyl-imidazol-1-yl)phenyl)-5(R)-hydroxymethyloxazolidin-2-one (202 mg, 0.69 mmol), and purifying by chromatography on a 10 g silica Mega Bond Elut® column, eluting with a gradient increasing in polarity from 0 to 2.5% MeOH in dichloromethane, the title compound was prepared (137 mg).

Provenance & Evidence