(5R)-3-[3-fluoro-4-(3-hydroxyazetidin-1-yl)phenyl]-5-(isoxazol-3-yloxymethyl)oxazolidin-2-one → (5R)-3-[3-fluoro-4-(4-methylimidazol-1-yl)phenyl]-5-(isoxazol-3-yloxymethyl)oxazolidin-2-one

Participants

Reaction Steps

Using essentially the same procedure as for the intermediate of Example 65, but starting with 3-(3-fluoro-4-(4-methyl-imidazol-1-yl)phenyl)-5(R)-hydroxymethyloxazolidin-2-one (see Example 141; 81 mg, 0.29 mmol), and purifying by chromatography on a 5 g silica Mega Bond Elut® column, eluting with a gradient increasing in polarity from 0 to 2.5% MeOH in dichloromethane, gave the title compound (80 mg). MS (ESP): 359 (MH+) for C17H15FN4O4.

Provenance & Evidence