Ethyl Acetate → HCID 21356576, compound

Participants

Reaction Steps

5-Ethoxycarbonylamino-2-((3R)-3-t-butyldimethylsilyloxy-1-pyrrolidinyl)fluorobenzene (29.4 g, 0.077 M) was treated in essentially the same way as the appropriate intermediate of Example 86, except that the product was isolated by extraction into EtOAc, and crude product purified by dry column chromatography on silica, eluting with a gradient from 0-20% MeOH in dichloromethane. Appropriate fractions were combined to give the desired product (29.6 g).

Provenance & Evidence