Water → HCID 817992, compound

Participants

Reaction Steps

The compound obtained in Step A (1 g; 7.19 mmol) is dissolved in 16 ml of water with the aid of concentrated hydrochloric acid (0.58 ml). Acetic anhydride (1.2 eq.; 8.62 mmol; 813 μl) is added to the red solution obtained. The mixture is homogenised and poured into 5 ml of a sodium acetate solution (1.7 eq.; 12.22 mmol; 1.075 g). After stirring the mixture for 15 minutes, the precipitate is filtered off using a Büchner funnel and then rinsed with water. The solid is subsequently dissolved in ethyl acetate and then dried over MgSO4. After filtration, the solvent is removed under reduced pressure to yield the title product in the form of a red solid.

Provenance & Evidence