HCID 8176949, compound → HCID 22993356, compound

Participants

Reaction Steps

The compound obtained in Step A (3 g; 10.44 mmol) is dissolved in a Parr reactor with an ethanol/tetrahydrofuran mixture (1/1). Raney nickel (30% by weight, 900 mg) is then added. The mixture is left for 48 hours at 50° C. under a hydrogen pressure of 50 psi. After returning to ambient temperature, the solution is filtered over Celite and the filtrate is evaporated. The crude reaction product is purified by flash chromatography on silica gel (eluant: PE/AcOEt (85/15)). The title product is obtained in the form of a yellow solid.

Provenance & Evidence