Bromoacetonitrile → HCID 22993355, compound

Participants

Reaction Conditions

Reaction Steps

The compound obtained in Step B (480 mg; 1.99 mmol) is suspended in 8 ml of water (4 ml/l mmol). Potassium hydrogen carbonate (10 eq.; 19.89 mmol; 1.657 g), tetrabutylammonium bromide (1 eq.; 1.99 mmol; 641 mg) and bromoacetonitrile (8 eq.; 15.91 mmol; 1.11 ml) are then added. The mixture is stirred vigorously at 90° C. for 8 hours. After returning to ambient temperature, the product formed is extracted with dichloromethane. The organic phase is dried over MgSO4, filtered, and then concentrated under reduced pressure. The residue obtained is purified by flash chromatography on silica gel (eluant: PE/AcOEt (8/2)). The title product is obtained in the form of a colourless oil.

Provenance & Evidence